P11.68.A Hemangiopericytoma, case series and clinic-pathological analysis

Abstract Background Hemangiopericytoma (HPC) is an extremely rare aggressive tumor of mesenchymal origin, which constitutes less than 1% primary tumors the central nervous system. Typically it occurs in young adults (mean age at diagnosis 30-50 years). Initially described as gemmangiomas, was first called hemangiopericytoma 1942 but considered a variant meningioma until 1993 when finally recognized distinct clinical-pathological entity by World Health Organization (WHO). In 2016, there unification both HPC and Solitary Fibrous Tumor (SFT) single spectrum thick due to identification, tumoral types, molecular alteration NAB2-STAT6 fusion. Material Methods The present study case series patients that received pathological SFT/HPC our Institute from 1981 2020. Clinical data included: demographic data, characteristics treatment modality. Hystological immunohistochemistry allowed confirm diagnosis, based on 2016 WHO classification. Haematoxylin staining completed with antibodies for STAT 6 evaluation presence necrosis. Statistical analysis conducted considering modality, extent resection, necrosis histological compared PFS-1, OS relapses number. Results composed 82 (46 men 36 women) median 43 (± 20) accede Our statistical showed significative correlation between age, extend resection Conclusion very cerebral tumors, this reason large are not disposable literature. we collected all every patient acceded hospital long period 39 years aim verify correlations. We observed strong tissue prognosis parameters (OS number relapses). This result could be important conduct decisional process about after surgical also features, rather only resection.